Ingredients
CalmGut™ Complex
Peppermint Leaf
Peppermint leaf is scientifically proven and well known for its soothing effects on the digestive tract. It can help relax muscles in the gastrointestinal tract, relieving symptoms of indigestion and promoting smoother digestion.
Ashwaganda
Ashwagandha, an adaptogenic herb, is renowned for its stress-relieving properties. It helps modulate the body’s response to stress, promoting a balanced and resilient digestive system. In the context of gut health, stress reduction can positively impact digestive function.
Theanine
Theanine, an amino acid found in tea leaves, is known for its calming and stress-reducing effects. By promoting a sense of relaxation without sedation, theanine can contribute to a harmonious balance within the body, potentially benefiting gut health through stress management.
Artichoke Leaf
Artichoke leaf is rich in compounds that support liver function and aid digestion. It has been traditionally used to alleviate bloating and indigestion, contributing to a healthier gut environment.
Ginger
Ginger is well-studied for its digestive benefits. It can suppress gastric contractions as well as reduce gut distress, offering comprehensive support for digestive well-being.
Curcumin
Curcumin, the active compound in turmeric, possesses powerful antioxidant properties. These properties can help mitigate aggravation in the gut, potentially improving digestive comfort and overall gut health.
Alpha Galactosidase
Alpha galactosidase is an enzyme that aids in the breakdown of complex carbohydrates, particularly those found in certain foods known to cause gas and bloating. Its inclusion in the supplement can support the digestion of these compounds, promoting a more comfortable digestive experience.
Enzyme Blend
Our 5 enzyme blend includes Amylase, Cellulase, Lactase, Lipase, and Neutral Protease. These enzymes are crucial for the digestion of dietary fats, sugars, plants, starches, and proteins. By breaking down these nutritional molecules into smaller components, the blend facilitates absorption, contributing to a smoother digestive process and nutrient assimilation.
StrongGut™ Complex
Fennel Seed
Fennel seed is used to ease digestive discomfort. It can help relax the muscles in the gastrointestinal tract, reducing bloating, and promoting overall digestive wellness.
Marshmallow Root
Marshmallow root contains mucilage, which can coat and soothe the digestive tract. This may assist in reducing irritation, providing relief for indigestion while helping building a resilient gut barrier.
Slippery Elm
Slippery elm has mucilaginous properties, forming a protective layer around the digestive tract’s lining. This can help alleviate irritation and aggravation, making it a valuable ingredient for supporting gastrointestinal health.
Clinical Studies
CalmGut™ Complex
Chumpitazi BP, Kearns GL, Shulman RJ. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders. Aliment Pharmacol Ther. 2018 Mar;47(6):738-752. doi: 10.1111/apt.14519. Epub 2018 Jan 26. PMID: 29372567; PMCID: PMC5814329.
Shukla R, Pahal S, Gupta A, Choudhary P, Misra K, Singh S. Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study. J Biomol Struct Dyn. 2023 Jul;41(10):4485-4503. doi: 10.1080/07391102.2022.2068072. Epub 2022 May 1. PMID: 35491707.
Xu W, Kong Y, Zhang T, Gong Z, Xiao W. L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism. J Sci Food Agric. 2023 Feb;103(3):1283-1293. doi: 10.1002/jsfa.12222. Epub 2022 Sep 23. PMID: 36087337.
Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
Holtmann G, Adam B, Haag S, Collet W, Grünewald E, Windeck T. Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial. Aliment Pharmacol Ther. 2003 Dec;18(11-12):1099-105. doi: 10.1046/j.1365-2036.2003.01767.x. PMID: 14653829.
Giacosa A, Guido D, Grassi M, et al. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evid Based Complement Alternat Med. 2015;2015:915087. doi:10.1155/2015/915087
Nikkhah Bodagh M, Maleki I, Hekmatdoost A. Ginger in gastrointestinal disorders: A systematic review of clinical trials. Food Sci Nutr. 2018 Nov 5;7(1):96-108. doi: 10.1002/fsn3.807. PMID: 30680163; PMCID: PMC6341159.
Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci. 2005 Nov;50(11):2191-3. doi: 10.1007/s10620-005-3032-8. PMID: 16240238.
Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6. doi: 10.1016/j.cgh.2006.08.008. Epub 2006 Nov 13. PMID: 17101300.
Kongkam P, Khongkha W, Lopimpisuth C, Chumsri C, Kosarussawadee P, Phutrakool P, Khamsai S, Sawanyawisuth K, Sura T, Phisalprapa P, Buamahakul T, Siwamogsatham S, Angsusing J, Poonniam P, Wanaratna K, Teerachaisakul M, Pongpirul K. Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial. BMJ Evid Based Med. 2023 Sep 11:bmjebm-2022-112231. doi: 10.1136/bmjebm-2022-112231. Epub ahead of print. PMID: 37696679.
Portincasa P, Bonfrate L, Scribano ML, Kohn A, Caporaso N, Festi D, Campanale MC, Di Rienzo T, Guarino M, Taddia M, Fogli MV, Grimaldi M, Gasbarrini A. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. J Gastrointestin Liver Dis. 2016 Jun;25(2):151-7. doi: 10.15403/jgld.2014.1121.252.ccm. PMID: 27308645
StrongGut™ Complex
Das B, Rabalais J, Kozan P, Lu T, Durali N, Okamoto K, McGeough MD, Lee BJ, Barrett KE, Marchelletta R, Sivagnanam M. The effect of a fennel seed extract on the STAT signaling and intestinal barrier function. PLoS One. 2022 Jul 8;17(7):e0271045. doi: 10.1371/journal.pone.0271045. PMID: 35802574; PMCID: PMC9269469.
Hage-Sleiman R, Mroueh M, Daher CF. Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharm Biol. 2011 Mar;49(3):327-33. doi: 10.3109/13880209.2010.516754. Epub 2011 Feb 1. PMID: 21281251.
Aleman RS, Paz D, Cedillos R, Tabora M, Olson DW, Aryana K. Attributes of Culture Bacteria as Influenced by Ingredients That Help Treat Leaky Gut. Microorganisms. 2023 Mar 30;11(4):893. doi: 10.3390/microorganisms11040893. PMID: 37110316; PMCID: PMC10144211.
Bonaterra GA, Schmitt J, Schneider K, Schwarzbach H, Aziz-Kalbhenn H, Kelber O, Müller J, Kinscherf R. Phytohustil® and root extract of Althaea officinalis L. exert anti-inflammatory and anti-oxidative properties and improve the migratory capacity of endothelial cells in vitro. Front Pharmacol. 2022 Dec 8;13:948248. doi: 10.3389/fphar.2022.948248. PMID: 36569306; PMCID: PMC9773075.
Karin Ried, Nikolaj Travica, Ranjini Dorairaj, Avni Sali,
Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive disorders,
Nutrition Research,
Volume 76, 2020, Pages 37-51, ISSN 0271-5317, (https://doi.org/10.1016/j.nutres.2020.02.008)(https://www.sciencedirect.com/science/article/pii/S027153171931187X)